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SML1496 Sigma-Aldrich

Buformin hydrochloride

≥98% (HPLC)

Synonym: 1-Butylbiguanide hydrochloride, N-Butyl-imidodicarbonimidic diamide hydrochloride

  • CAS Number 1190-53-0

  • Empirical Formula (Hill Notation) C6H15N5 · HCl

  • Molecular Weight 193.68

  •  NACRES NA.77

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Properties

Related Categories AMP-Activated Protein Kinase (AMPK), B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 25 mg/mL, clear
storage temp.   −20°C

Description

Packaging

50 mg in glass bottle

Biochem/physiol Actions

Buformin is an oral antidiabetic drug with antiproliferative properties; AMPK activator. Buformin, an antidiabetic biguanide drug, was withdrawn as an antidiabetic drug in several countries because of the side effect of lactic acidosis, but is now being investigated as an anticancer agent. Buformin inhibits the growth and development of cancer. Buformin has been shown to postpone spontaneous carcinogenesis as well as inhibit induced carcinogenesis in animal studies. Buformin decreased cancer incidence, multiplicity, and burden in a rat study of chemically induced mammary carcinogenesis. Buformin also reduced renal cell carcinoma survival under conditions of glucose deprivation. Buformin′s anticancer activity is thought to involve disruption of the Warburg effect by AMPK activation, which decreases hepatic glucose production, and inhibition of the mTor pathway.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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