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SML1498 Sigma-Aldrich

Cinepazide maleate

≥98% (HPLC)

Synonym: (E)-1-[4-(2-Oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one maleate, 1-(Pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate

  • CAS Number 26328-04-1

  • Empirical Formula (Hill Notation) C22H31N3O5 · C4H4O4

  • Molecular Weight 533.57

  •  MDL number MFCD01320526

  •  PubChem Substance ID 329825922

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Properties

Related Categories Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C(O)/C=C\C(O)=O.O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
InChI   1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-
InChI key   XSTJTOKYCAJVMJ-GVTSEVKNSA-N

Description

General description

Cinepazide maleate can be synthesized from ethyl chlorocarbonate activation and (E) 3,4,5-trimethoxycinnamylic acid.

Packaging

50 mg in glass bottle

Biochem/physiol Actions

Cinepazide maleate is a vasodilator used clinically in China used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. Cinepazide maleate is thought to act as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker. It was withdrawn for agranulocytosis in several countries.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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