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SML1511 Sigma-Aldrich

CS1

≥98% (HPLC)

Synonym: 4-(6-Hydroxy-2-naphthalenyl)-1,2-benzenediol

  • CAS Number 1448009-94-6

  • Empirical Formula (Hill Notation) C16H12O3

  • Molecular Weight 252.26

  •  PubChem Substance ID 329825928

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to light brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   OC1=CC=C2C(C=CC(C3=CC(O)=C(O)C=C3)=C2)=C1
InChI   1S/C16H12O3/c17-14-5-3-11-7-10(1-2-12(11)8-14)13-4-6-15(18)16(19)9-13/h1-9,17-19H
InChI key   LDFFDYWHCCDSBO-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. CS1 is a nonintercalating topoisomerase IIα (Topo IIα) inhibitor, which stabilizes the DNA-Topo IIα cleavage complex.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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