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SML1516 Sigma-Aldrich

DS-437

≥98% (HPLC)

Synonym: 5′-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine

  • CAS Number 1674364-87-4

  • Empirical Formula (Hill Notation) C15H23N7O4S

  • Molecular Weight 397.45

  •  PubChem Substance ID 329825933

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
InChI   1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
InChI key   CACMCLIHCDTJHL-XNZUMOJTSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

Other Notes

DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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