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SML1579 Sigma-Aldrich

MS4

≥98% (HPLC)

Synonym: ((11S,17R)-17-(2-(Benzo[d]thiazol-2-ylthio)acetyl)-11,17-dihydroxy-10-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one, (11)-21-(2-Benzothiazolylthio)-11,17-dihydroxy-pregn-4-ene-3,20-dione, Mercaptosteroid 4

  • CAS Number 1166869-57-3

  • Empirical Formula (Hill Notation) C28H33NO4S2

  • Molecular Weight 511.70

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +130 to +160°, c = 0.54 in dichloromethane
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MS4 (mercaptosteroid 4), a thiobenzothiazole-containing derivative of hydrocortisone, is a glucocorticoid receptor (GR) agonist that exhibits potent anti-inflammatory properties with reduced impact on insulin secretion. MS4 strongly repress CCL2 and CCL20 synthesis and secretion. MS4 exhibits reduced toxicity towards cultured b-cells, and does not promote adipogenesis or gluconeogenic gene expression in primary hepatocytes. MS4 could potentially be used to improve islet transplantation protocols.

Safety & Documentation

Safety Information

Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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