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SML1583 Sigma-Aldrich

Roseoflavin

≥95% (HPLC)

Synonym: 8-Demethyl-8-(dimethylamino)-riboflavin, 8-Dimethylaminoriboflavin

  • CAS Number 51093-55-1

  • Empirical Formula (Hill Notation) C18H23N5O6

  • Molecular Weight 405.41

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
assay   ≥95% (HPLC)
form   powder
storage condition   protect from light
color   , white to very dark brown
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Roseoflavin is an analog of flavin mononucleotide (FMN) and riboflavin with antimicrobial activity. Roseoflavin is converted to the flavin mononucleotide (FMN) analog roseoflavin mononucleotide (RoFMN) by flavokinase and to the flavin adenine dinucleotide (FAD) analog roseoflavin adenine dinucleotide (RoFAD) by FAD synthetase, and acts as a riboflavin antagonist. Roseoflavin is an inhibitor of bacterial riboflavin riboswitches, cis regulatory elements present in non-coding RNA that specifically bind to natural ligands to regulate gene expression. Roseoflavin, converted to RoFMN, blocks the flavin mononucleotide riboswitch-mediated expression of the ribB gene, which is required for riboflavin biosynthesis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
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