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SML1605 Sigma-Aldrich

OTX015

≥98% (HPLC)

Synonym: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-, OTX-015

  • CAS Number 202590-98-5

  • Empirical Formula (Hill Notation) C25H22ClN5O2S

  • Molecular Weight 491.99

  •  MDL number MFCD26960949

  •  PubChem Substance ID 329825491

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
InChI   1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
InChI key   GNMUEVRJHCWKTO-FQEVSTJZSA-N
Gene Information   human ... BRD2(6046), BRD3(8019), BRD4(23476), BRDT(676)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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