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SML1664 Sigma-Aldrich

Deoxynivalenol Ready Made Solution

1 mg/mL

Synonym: (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 4-Deoxynivalenol, DON, Dehydronivalenol, RD-toxon, Vomitoxin

  • CAS Number 51481-10-8

  • Empirical Formula (Hill Notation) C15H20O6

  • Molecular Weight 296.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics More...
biological source   Fusarium sp. (Fusarium asiaticum)
form   solution (ethanol: 2-propanol 95:5)
storage condition   protect from light
concentration   1 mg/mL
shipped in   dry ice
storage temp.   −20°C

Description

Preparation Note

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Biochem/physiol Actions

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

Safety & Documentation

Safety Information

RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution

Documents

Certificate of Analysis

Protocols & Articles
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