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SML1673 Sigma-Aldrich

MM-206

≥98% (HPLC)

Synonym: 2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide, MM 206

  • CAS Number 1809581-87-0

  • Empirical Formula (Hill Notation) C22H12F5NO3S2

  • Molecular Weight 497.46

  •  MDL number MFCD30179936

  •  PubChem Substance ID 329826008

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage temp.   2-8°C
SMILES string   OC(C1=C2C=CC=C1)=C(SC3=CC=CC=C3)C=C2NS(C4=C(F)C(F)=C(F)C(F)=C4F)(=O)=O

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity (IC50 = 2.45 μM). MM-206 inhibits G-CSF-stimulated STAT3 phosphorylation in human AML cells (IC50 = 0.8-1.9 μM) and exhibits higher apoptosis-inducing potency in AML (EC50 in μM = 6.3/p198, 7.1/MV4-11 and 7.6/HL-60) than ALL cultures (EC50 in μM = 26.0/KOPN-8 & 42.2/RS4-11). When administered via daily i.p. dosing (30 mg/kg), MM-206 is efficacious in prolonging the survival of mice received MV4-11 AML xenograft.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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