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SML1685 Sigma-Aldrich

Ribocil-C

≥98% (HPLC)

Synonym: 2-[(3S)-1-[[1-(2-Pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-4(3H)-pyrimidinone

  • CAS Number 1825355-56-3

  • Empirical Formula (Hill Notation) C21H21N7OS

  • Molecular Weight 419.50

  •  MDL number MFCD29472282

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches. Riboswitches are cis regulatory elements present in non-coding RNA that specifically bind to natural ligands to regulate gene expression. Ribocil-C blocks the flavin mononucleotide riboswitch-mediated expression of the ribB gene, which is required for riboflavin biosynthesis, with an IC50 value of 23 nM. Ribocil-C inhibited bacterial cell growth of E. coli MB5746 and bacterial burden in a mouse E. coli septicaemia model of infection.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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