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SML1692 Sigma-Aldrich

AS8351

≥98% (HPLC)

Synonym: 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone, 311 Iron Chelator, AS-8351, NSC-51355

  • CAS Number 796-42-9

  • Empirical Formula (Hill Notation) C17H13N3O2

  • Molecular Weight 291.30

  •  MDL number MFCD00033110

  •  PubChem Substance ID 329826020

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Properties

Related Categories AN-AZ, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O
InChI   1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
InChI key   WQSHHAVECQJKLX-YBFXNURJSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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