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SML1706 Sigma-Aldrich

BRD4354

≥98% (HPLC)

Synonym: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol

  • CAS Number 315698-07-8

  • Empirical Formula (Hill Notation) C21H23ClN4O

  • Molecular Weight 382.89

  •  PubChem Substance ID 329826031

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 3 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BRD4354 is a zinc chelating, reversible inhibitor of zinc-dependent histone deacetylases with selectivity for HDAC5 and HDAC9. BRD4354 has IC50 values of 0.85 μM and 1.88 μM for HDAC5 and HDAC9 respectively. Inhibition of other HDACs was lower, with IC50 values of 3.88-13.8 μM for HDACs 4, 6, 7, and 8 and over 40 μM for HDACs 1, 2, and 3. BRD4354′s mechanism is believed to involve zinc-catalyzed decomposition to an ortho-quinone methide, which covalently modifies nucleophilic cysteines within the proteins.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
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