EMAIL THIS PAGE TO A FRIEND
SML1724 Sigma-Aldrich

Displurigen

≥98% (HPLC)

Synonym: 8-Hydroxy-1,1-dioxo-2-phenylthiochromen-4-one, 8-Hydroxy-2-phenyl-4H-1-benzothiopyran-4-one-1,1-dioxide, 8-Hydroxy-2-phenyl-4H-thiochromen-4-one 1,1-dioxide

  • CAS Number 96156-26-2

  • Empirical Formula (Hill Notation) C15H10O4S

  • Molecular Weight 286.30

  •  PubChem Substance ID 329826039

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   O=C(C=C1C2=CC=CC=C2)C3=C(C(O)=CC=C3)S1(=O)=O

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Displurigen is a cell-permeable, phenylthiochromen-4-one derived compound that disrupts the pluripotency of human embryonic stem cells by targeting HSPA8/HSC70 and affects its binding to Oct4. Inhibits ATPase activity of HSP70 (IC50 = 225 μM). Displurigen has shown to diminish the mRNA levels of Oct4 and Nanog within 24 hours of treatment and causes a complete annihilation of OCT4+  and NANOG+  bearing cells within 4 days of treatment (~ 10 μM). It does not induce apoptosis and has no significant effect on cell cycle progression.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?