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SML1726 Sigma-Aldrich

MSAB

≥95% (HPLC)

Synonym: 3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester, Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate, WI-21

  • CAS Number 173436-66-3

  • Empirical Formula (Hill Notation) C15H15NO4S

  • Molecular Weight 305.35

  •  PubChem Substance ID 329826041

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
color   off-white to purple
solubility   DMSO: 25 mg/mL, clear
storage temp.   2-8°C
SMILES string   CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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