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SML1747 Sigma-Aldrich

JNJ-55511118

≥98% (HPLC)

Synonym: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one

  • Empirical Formula (Hill Notation) C14H8ClF3N2O2

  • Molecular Weight 328.67

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitor, mainly in the hippocampus region.

JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors that requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampus, and a strong anti-convulsant effect.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Making Headway
Protocols & Articles
Peer-Reviewed Papers
15

References

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