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SML1831 Sigma-Aldrich

KYA1797K potassium salt

≥98% (HPLC)

Synonym: (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt, (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid potassium salt, KYA1797 potassium salt

  • CAS Number 1956356-56-1

  • Empirical Formula (Hill Notation) C17H11KN2O6S2

  • Molecular Weight 442.51

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   orange to dark red
solubility   DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   [O-]C(CCN1C(/C(SC1=S)=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O)=O.[K+]

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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