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SML1835 Sigma-Aldrich

DSHN

≥98% (HPLC)

Synonym: 5-(Diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid, 5-[(Diethylamino)sulfonyl]-3-hydroxy-2-naphthalenecarboxylic acid

  • CAS Number 313952-63-5

  • Empirical Formula (Hill Notation) C15H17NO5S

  • Molecular Weight 323.36

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   CCN(CC)S(C1=CC=CC2=CC(C(O)=O)=C(O)C=C21)(=O)=O

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DSHN is a potent and selective activator of SHP (small heterodimer partner, NR0B2) that transcriptionally activates SHP mRNA and stabilized the SHP protein by preventing its ubiquitination and degradation. DSHN potently inhibits HCC cell migration and invasivnes by suppression of CCL2 expression.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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