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SML1852 Sigma-Aldrich

8-Aminoguanosine

≥98% (HPLC)

Synonym: 2,8-Diamino-inosine, NSC 90390

  • CAS Number 3868-32-4

  • Empirical Formula (Hill Notation) C10H14N6O5

  • Molecular Weight 298.26

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to brown
solubility   DMSO: 1 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   NC1=NC(C2=C(N1)N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)=O
InChI   1S/C10H14N6O5/c11-9-14-6-3(7(20)15-9)13-10(12)16(6)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H2,12,13)(H3,11,14,15,20)
InChI key   FNXPTCITVCRFRK-UHFFFAOYSA-N

Description

Packaging

25 mg in glass bottle

Biochem/physiol Actions

8-Aminoguanosine is known to stimulate diuresis, natriuresis, glucosuria and antikaliuresis. It is an analog of guanosine, that can block purine nucleoside phosphorylase, in vitro and in intact lymphoid cells. 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli.

8-Aminoguanosine, a guanosine derivative, is an orally available and highly efficacious potassium-sparing diuretic/natriuretic that increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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