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SML1868 Sigma-Aldrich

Brusatol

≥95% (HPLC)

Synonym: (+)-Brusatol, (11β,12α,15β)-13,20-Epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid methyl ester, Brutasol, NSC 172924, Yatansin

  • CAS Number 14907-98-3

  • Empirical Formula (Hill Notation) C26H32O11

  • Molecular Weight 520.53

  •  MDL number MFCD23726642

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
biological source   (Brucia javanica)
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D +35 to +44°, c = 0.5 in acetone
storage condition   desiccated
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Application

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2.

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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