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SML1872 Sigma-Aldrich

ORM-3819

≥98% (HPLC)

Synonym: 4-Hydroxy-3-methoxy-2-nitro-benzaldehyde 2-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazone, L-6-{4-[N′-(4-Hydroxi-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl}-5-methyl-4,5-dihydro-2 H-pyridazin-3-one

  • CAS Number 360794-85-0

  • Empirical Formula (Hill Notation) C19H19N5O5

  • Molecular Weight 397.38

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Antagonists, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   light orange to dark orange
solubility   DMSO: 30 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C(C[C@H]1C)NN=C1C(C=C2)=CC=C2NN=CC3=C([N+]([O-])=O)C(OC)=C(O)C=C3

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ORM-3819 is a potent inotropic agent that binds to cardiac troponin C (cTnC) and sensitizes heart to Ca2+. Also, ORM-3819 is a selective and potent inhibitor of PDE III. ORM-3819 exhibits positive inotropic effects through Ca2+-sensitization and selective inhibition of PDE III. ORM-3819 was effective in vivo dog model of myocardial stunning.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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