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SML1874 Sigma-Aldrich

DM-NOFD

≥98% (HPLC)

Synonym: Dimethyl N-oxalyl-D-phenylalanine, N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester, N-Oxalyl-D-phenylalanine dimethyl ester

  • CAS Number 865488-53-5

  • Empirical Formula (Hill Notation) C13H15NO5

  • Molecular Weight 265.26

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
Quality Level   100
assay   ≥98% (HPLC)
form   oil
color   , colorless to dark yellow
storage temp.   2-8°C
SMILES string   O=C(C(N[C@H](CC1=CC=CC=C1)C(OC)=O)=O)OC

Description

General description

Dimethyl N-oxalyl-D-phenylalanine (DM-NOFD) is a small FIH (factor-inhibiting) inhibitor molecule.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). DM-NOFD efficiently reduces HIF1a CAD (C-terminal activating domain) hydroxylation in MCF-7 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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