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SML1891 Sigma-Aldrich

PK11007

≥98% (HPLC)

Synonym: 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid

  • CAS Number 38275-34-2

  • Empirical Formula (Hill Notation) C6H5ClN2O4S

  • Molecular Weight 236.63

  •  MDL number MFCD00507244

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Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 10 mg/mL, clear
storage temp.   2-8°C

Description

Biochem/physiol Actions

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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