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SML1942 Sigma-Aldrich

Drotaverine hydrochloride

≥95% (HPLC)

Synonym: 1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, 3′,4′,6,7-Tetraethoxy-1-benzylidene-1,2,3,4-tetrahydroisoquinoline hydrochloride, Drotaverin hydrochloride, Tetraspasmin-Lefa

  • CAS Number 985-12-6

  • Empirical Formula (Hill Notation) C24H31NO4 · HCl

  • Molecular Weight 433.97

  •  MDL number MFCD00347721

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, DIG-DY
Quality Level   100
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   CCOC1=CC=C(/C=C2C3=C(CCN/2)C=C(OCC)C(OCC)=C3)C=C1OCC.[H]Cl
InChI   1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
InChI key   JBFLYOLJRKJYNV-MASIZSFYSA-N

Description

Biochem/physiol Actions

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker that exhibits in vivo antispasmodic efficacy without anticholinergic effects.

It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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