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SML1954 Sigma-Aldrich

X-34

≥90% (HPLC)

Synonym: 1,4-Bis(3-carboxy-4-hydroxyphenylethenyl)benzene

  • CAS Number 215294-98-7

  • Empirical Formula (Hill Notation) C24H18O6

  • Molecular Weight 402.40

  •  MDL number MFCD30474509

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, X
Quality Level   100
assay   ≥90% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2.0 mg/mL, clear
storage temp.   2-8°C
SMILES string   OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2

Description

Biochem/physiol Actions

Fluorescent, amyloid-specific dye

X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer′s disease (AD).

X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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