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SML2264 Sigma-Aldrich

Col003

≥98% (HPLC)

Synonym: 2-Hydroxy-3-nitro-5-(phenylmethyl)benzaldehyde

  • CAS Number 328565-16-8

  • Empirical Formula (Hill Notation) C14H11NO4

  • Molecular Weight 257.24

  •  MDL number MFCD00852947

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   OC1=C(C=C(C=C1C=O)CC2=CC=CC=C2)[N+]([O-])=O

Description

Biochem/physiol Actions

Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. It binds to the collagen binding site on Hsp47. Col003 inhibits a collagen secretion by destabilization the collagen triple helix. Additionally Col003 weakly inhibits interaction of collagen with prolyl 4-hydroxylase (P4H).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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