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SML2386 Sigma-Aldrich

Cycloguanil hydrochloride

≥95% (HPLC)

Synonym: 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride

  • CAS Number 152-53-4

  • Empirical Formula (Hill Notation) C11H14ClN5 · HCl

  • Molecular Weight 288.18

  •  MDL number MFCD00035308

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 2 mg/mL, clear
storage temp.   −20°C
InChI   1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
InChI key   MOUAPRKJJUXEIE-UHFFFAOYSA-N

Description

Application

Cycloguanil hydrochloride is suitable for use as a positive control in screening Plasmodium falciparum strains in microdilution radioisotope antiplasmodial bioassay. It may also be used as internal standard in high performance liquid chromatography for the quantification of urine and plasma samples.

Biochem/physiol Actions

Cycloguanil is it a potential antimalarial drug. It is hydrophilic in nature. Cycloguanil acts as a substrate for the enzyme organic cation transporter 1 (OCT1).

Cycloguanil, a metabolite of proguanil, is a potent dihydrofolate reductase inhibitor.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 3
RTECS 
GU2625000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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