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SML2469 Sigma-Aldrich

Oxanthroquinone G01

≥98% (HPLC)

Synonym: 9,10-Dihydro-8-hydroxy-3-methoxy-1,7-dimethyl-9,10-dioxo-2-anthracenecarboxylic acid ethyl ester, G01

  • CAS Number 1616622-15-1

  • Empirical Formula (Hill Notation) C20H18O6

  • Molecular Weight 354.35

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
assay   ≥98% (HPLC)
form   powder
color   faint yellow to dark orange
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C1C2=C(C=C(OC)C(C(OCC)=O)=C2C)C(C3=CC=C(C)C(O)=C31)=O

Description

Biochem/physiol Actions

Oxanthroquinone G01 is a potent inhibitor of KRAS and NRAS plasma membrane localization that potently inhibits proliferation of KRAS transformed cancer cells. Oxanthroquinone G01 also inhibits recycling of epidermal growth factor receptor and transferrin receptor, but has no influence on cholera toxin internalization. It also increases cellular levels of sphingomyelin and and ceramide.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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