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SML2487 Sigma-Aldrich

Cabazitaxel

≥95% (HPLC)

Synonym: 1-hydroxy-7β,10β-dimethoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(tert-butoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate], DEP cabazitaxel, Jevtana, TXD 258, XRP 6258, XRP-6258, dimethoxydocetaxel

  • CAS Number 183133-96-2

  • Empirical Formula (Hill Notation) C45H57NO14

  • Molecular Weight 835.93

  •  MDL number MFCD18827611

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Properties

assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D -36 to -44°, c = 0.5 in methanol
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   −20°C

Description

Biochem/physiol Actions

Cabazitaxel is a synthetic taxane microtubule inhibitor and anticancer agent. It acts by stabilization of microtubules, promoting tubulin assembly into microtubules but inhibiting disassembly, resulting in the inhibition of mitotic and interphase cellular functions.

Safety & Documentation

Safety Information

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Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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