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SML2622 Sigma-Aldrich

ABC1183

≥98% (HPLC)

Synonym: 4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile, 4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-benzonitrile

  • CAS Number 1042735-18-1

  • Empirical Formula (Hill Notation) C18H14N4OS

  • Molecular Weight 334.39

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Properties

assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   NC1=C(C(C2=CC=C(C=C2)C#N)=O)SC(NC3=CC=C(C)C=C3)=N1

Description

Biochem/physiol Actions

ABC1183 is an orally active, potent and selective inhibitor of GSK3 α/β and CDK9, which induces G2/M cell cycle arrest and apoptosis in cancer cells. Apparently ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms due to down regulation of TNFα and IL-6 pro-inflammatory cytokines. It does not exhibit organ or hematological toxicities.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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