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SML2675 Sigma-Aldrich

CuET

≥97% (HPLC)

Synonym: Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)

  • CAS Number 13681-87-3

  • Empirical Formula (Hill Notation) C10H20CuN2S4

  • Molecular Weight 360.09

  •  MDL number MFCD00070506

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology
assay   ≥97% (HPLC)
form   powder
storage condition   desiccated
color   dark green to black
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S

Description

Biochem/physiol Actions

CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
RTECS 
EZ5250000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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