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SML2816 Sigma-Aldrich

BS46 bromide

≥98% (HPLC)

Synonym: (1R,2R,4S,5S,7S)-7-[({4-Fluoro-2-(thiophen-2-yl)phenyl}carbamoyl)oxy]-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide

  • Empirical Formula (Hill Notation) C20H22BrFN2O3S

  • Molecular Weight 469.37

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   −20°C
SMILES string   FC1=CC=C(NC(O[C@@H]2C[C@H]([C@@H]3[C@H]4O3)[N+](C)(C)[C@H]4C2)=O)C(C5=CC=CS5)=C1.[Br-]

Description

Biochem/physiol Actions

BS46 is a highly potent and selective muscarinic acetylcholine receptor antagonist that exhibits 33-fold preference for M3R (M3 muscarinic acetylcholine receptor) over M2R. It fully inhibits carbachol-induced inositol monophosphate accumulation as well as ?-arrestin recruitment at M3Rs. BS46 exhibits 100,000-fold selectivity for muscarinic receptors against 21 aminergic and peptidergic GPCRs.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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