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SML2886 Sigma-Aldrich

O4I3

≥98% (HPLC)

Synonym: 2-(4-Methylphenyl)-6-methylimidazo[1,2-a]pyridine, 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine, OCT4-inducing compound 3

  • CAS Number 88965-00-8

  • Empirical Formula (Hill Notation) C15H14N2

  • Molecular Weight 222.29

  •  MDL number MFCD00444739

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   CC1=CC=C(C2=CN3C=C(C=CC3=N2)C)C=C1

Description

Biochem/physiol Actions

O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC50 = 0.15 nM vs KDM5B/C/D IC50 = 125.2/9.76/4.7 nM, KDM4 IC50 = 249 nM, LSD1 IC50 >100 μM) that effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
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References

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