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SML2896 Sigma-Aldrich

ONO-2506

≥98% (HPLC)

Synonym: (-)-(2R)-2-Propyloctanoic acid, (2R)-2-Propyloctanoic acid, (R)-2-Propyloctanoic acid, (R)-(-)-2-Propyloctanoic acid, Arundic acid, ONO 2506, ONO2506

  • CAS Number 185517-21-9

  • Empirical Formula (Hill Notation) C11H22O2

  • Molecular Weight 186.29

  •  MDL number MFCD08458423

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
Quality Level   100
assay   ≥98% (HPLC)
form   oil
color   colorless to yellow
storage temp.   −20°C

Description

Biochem/physiol Actions

ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-β-peptide (Aβ)-induced glial death in astrocyte cultures (50 μM ONO-2506 against 200 μM Aβ25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson′s disease (30 mg/kg ip mice).

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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