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SRE0050 Sigma-Aldrich

Aprotinin from bovine lung

saline solution, 3-7 TIU/mg protein, Suitable for manufacturing of diagnostic kits and reagents

Synonym: Aprotinin from bovine lung, BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

  • CAS Number 9087-70-1

  • Empirical Formula (Hill Notation) C284H432N84O79S7

  • Molecular Weight 6511.44

  •  MDL number MFCD00130541

  •  NACRES NA.32

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Properties

Quality Level   400
form   saline solution
mol wt   ~6,500
shipped in   wet ice
storage temp.   2-8°C
InChI key   ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Description

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Unit Definition

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
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