SRP0324 Sigma-Aldrich

MECP2 human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Synonym: MRX16, PPMX, RTS, methyl CpG binding protein 2 (Rett syndrome)

  •  NACRES NA.32



Related Categories Demethylases, Epigenetics, Histone Modifying Enzymes, Molecular Biology, Proteins and Peptides for Epigenetic Research More...
biological source   human
recombinant   expressed in E. coli
assay   ≥70% (SDS-PAGE)
form   aqueous solution
mol wt   36 kDa
packaging   pkg of 50 μg
NCBI accession no.   NM_004992
UniProt accession no.   P51608
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... MECP2(4204)


General description

Human recombinant Methyl CpG binding Protein 2 (Rett syndrome) (MECP2), (GenBank Accession No. NM_004992), amino acids 78-162 with N-terminal GST-tag, MW= 36 kDa, expressed in an E. coli expression system.

Methyl-CpG binding protein 2 (MECP2) is encoded by the gene mapped to human chromosome Xq28. Higher molecular weight form of hMeCP2 is expressed in frontal cortex nuclear and synaptic fractions, and in lymphoid cells. Fibroblast and lymphoblastoid strains of female patients with Rett syndrome and MeCP2 transfected cells also show expression of high molecular weight form of MeCP2.2The encoded chromosomal protein is characterized with the 80 amino acid-containing methyl-CpG binding domain, involved in chromosomal localization of the protein.


Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

Methyl-CpG binding protein 2 (MECP2) plays a vital role in regulation of a wide range of genes in the hypothalamus, and aids in both activation and repression of transcription. Mutation of the gene leads to a severe neurodevelopmental disorder associated with hypotonia, spasticity, severe learning disability, delayed psychomotor development, and recurrent pulmonary infections in males. Impairment in the expression of MeCP2 protein results in various neurological disorders such as Rett syndrome and Autism.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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