SRP0375 Sigma-Aldrich

LOXL2 human

recombinant, expressed in FreeStyle 293-F cells, ≥86% (SDS-PAGE)

Synonym: LOR2, WS9-14, lysyl oxidase-like 2



Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Extracellular Matrix Peptides and Proteins More...
biological source   human
recombinant   expressed in FreeStyle 293-F cells
assay   ≥86% (SDS-PAGE)
form   aqueous solution
mol wt   85 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
concentration   0.23 mg/mL
NCBI accession no.   NM_002318
UniProt accession no.   Q9Y4K0
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... LOXL2(4017)


General description

Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.

Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.

Biochem/physiol Actions

Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.

Physical form

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

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