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SRP2045 Sigma-Aldrich

PPAR, γ human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Synonym: CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma

  •  NACRES NA.26

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥70% (SDS-PAGE)
form   frozen liquid
mol wt   ~60 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
concentration   500 μg/mL
application(s)   ligand binding assay: suitable
color   clear colorless
NCBI accession no.   NM_138712
UniProt accession no.   P37231
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PPARG(5468)

Description

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPAR α is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR β is found in many tissues but the highest expression is in the gut, kidney and heart. PPAR γ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. The target genes of PPAR α are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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