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SRP2073 Sigma-Aldrich

N-CoR human

recombinant, expressed in insect cells, ≥60% (SDS-PAGE)

Synonym: KIAA1047, MGC104216, N-CoR1, N-CoR, TRAC1, hN-CoR

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression
biological source   human
recombinant   expressed in insect cells
assay   ≥60% (SDS-PAGE)
form   frozen liquid
mol wt   ~271 kDa
packaging   pkg of 5 μg
concentration   700 μg/mL
application(s)   deacetylase assay: suitable
color   clear colorless
NCBI accession no.   NM_006311
UniProt accession no.   O75376
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... NCOR1(9611)

Description

Biochem/physiol Actions

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

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