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SRP2086 Sigma-Aldrich

p300 (C1135-2414) human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonym: KAT3B, RP1-85F18.1, RSTS2, p300

  •  NACRES NA.26

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression
biological source   human
recombinant   expressed in insect cells
assay   ≥70% (SDS-PAGE)
form   frozen liquid
mol wt   ~145 kDa
packaging   pkg of 4 μg
concentration   350 μg/mL
color   clear colorless
NCBI accession no.   NM_001429
UniProt accession no.   Q09472
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... EP300(2033)

Description

General description

E1A binding protein p300 (p300) has a central bromodomain and three cysteine- and histidine-rich regions. The carboxy-terminal region interacts with the adenovirus oncoprotein E1A. The gene encoding this protein is localized on human chromosome 22q13.

Biochem/physiol Actions

Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with a variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as a tumor suppressor. The C-terminus of p300 contains a histone acetyltransferase (HAT) domain expanded from residues 1195 to 1673, an activation domain (residues 1763-1812) that interacts with many transcription factors and an SRC-1 domain further down stream of the activation domain. P300 is able to acetylate histones and many other transcription factors, including p53, E2F, TFIIE, and TFIIF etc. implicating diverse roles of p300 in gene regulation.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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