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  • SRP2096 - p300-Ch1 (302-531) human

SRP2096 Sigma-Aldrich

p300-Ch1 (302-531) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym: KAT3B, RP1-85F18.1, RSTS2, p300

  •  NACRES NA.26



Related Categories Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression
biological source   human
recombinant   expressed in E. coli
assay   ≥80% (SDS-PAGE)
form   frozen liquid
mol wt   ~26 kDa
packaging   pkg of 10 μg
concentration   1000 μg/mL
color   clear colorless
NCBI accession no.   NM_001429
UniProt accession no.   Q09472
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... EP300(2033)


General description

The EP300 (E1A binding protein p300) gene is mapped to human chromosome 22q13.2. It codes for a histone acetyltransferase which is ubiquitously expressed.

Biochem/physiol Actions

Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as tumor suppressors. The ability of p300 to acetylate many transcription factors, including p53, E2F, TFIIE, and TFIIF etc. demonstrated a novel mechanism of targeted p300 regulation of gene expression.

Loss of EP300 (E1A binding protein p300) gene function causes Rubinstein-Taybi syndrome. p300 is essential for cell differentiation, growth and survival. p300 promotes liver stiffness, which is known to induce hepatic stellate cell differentiation to tumor-promoting myofibroblasts.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers


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