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SRP3030 Sigma-Aldrich

ENA-78 (8-78) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: CXCL5, Epithelial Neutrophil Activating Peptide-78, LIX (murine)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
potency   10.0-100.0 ng/mL
mol wt   7.8 kDa
packaging   pkg of 20 μg
impurities   <0.1 EU/μg endotoxin, tested
color   white to off-white
suitability   cell culture tested
UniProt accession no.   P42830
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CXCL5(6374)

Description

General description

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues. The ENA-78 gene is mapped to human chromosome 4q13.3.

Biochem/physiol Actions

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) gene expression is associated with sepsis, atherosclerosis, COPD (chronic obstructive pulmonary disease), psoriasis and gastrointestinal inflammation. ENA-78 is angiogenic factor and is associated with cancer progression. Upregulation of ENA-78 gene is observed in non‐small‐cell lung cancer, head, neck, gastric, pancreatic, colorectal, prostate and lung cancer squamous cell carcinoma.

ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.

Sequence

LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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