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SRP3035 Sigma-Aldrich

Exodus-2 (CCL21) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: 6Ckine, CCL21, SLC

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
potency   10.0-100.0 ng/mL
mol wt   12.2 kDa
packaging   pkg of 20 μg
impurities   <0.1 EU/μg endotoxin, tested
color   white to off-white
suitability   cell culture tested
UniProt accession no.   O00585
  O00585
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CCL21(6366)

Description

General description

Exodus-2 or C-C motif chemokine ligand 21 (CCL21) is a CC chemokine that signals through the C-C chemokine receptor-7 (CCR7). It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. CCL21 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. The gene encoding this protein is localized on human chromosome 9p13. Recombinant human Exodus-2 is a 12.2kDa protein containing 111 amino acid residues.

Biochem/physiol Actions

Exodus-2 aids in the migration of lymphocytes and dendritic cells to lymph nodes. This is observed in ulcerative colitis. It also chemoattracts T and B lymphocytes and inhibits hematopoiesis. The protein may have a role in the metastasis of pancreatic cancer stem cells. CCL21 has been associated with lymph node metastasis in gastric carcinoma.

Sequence

SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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