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SRP3059 Sigma-Aldrich

Interferon-λ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: IFN-λ human, IL-29

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
potency   0.2-0.5 ng/mL ED50
mol wt   19.8 kDa
packaging   pkg of 20 μg
impurities   <0.1 EU/μg endotoxin, tested
color   white to off-white
suitability   cell culture tested
UniProt accession no.   Q8IU54
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IL29(282618)

Description

General description

IFN-λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family of interferons. All three IFN-λs use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant human IFN-L1 is a 19.8kDa protein containing 178 amino acid residues.

Biochem/physiol Actions

Interleukin-29 (IL-29) enhances the production of interleukins from monocytes. It has been observed that it stimulates antiviral responses to herpes simplex virus 1 in vitro. Serums from patients with rheumatoid arthritis have high levels of IL29.

Sequence

PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Physical form

Lyophilized from 1x PBS.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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