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SRP3094 Sigma-Aldrich

IL-4 Receptor human

recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: CD124, soluble IL-4 receptor alpha

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Description

Biochem/physiol Actions

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gc). Recombinant human sIL-4Ra is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Ra.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Physical form

Lyophilized from 1x PBS pH 7.0.

General description

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gc). The type I receptor contains in addition to the gc an IL-4Rα subunit, whereas the type II receptor contains the IL-13Ra. The secreted extracellular domain of IL-4Ra, called sIL-4Ra, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Rα.

Sequence

GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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