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SRP3180 Sigma-Aldrich

TWEAK Receptor human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym: FGF-inducible 14, TNF-related weak inducer of apoptosis receptor, TNFRSF12A

  •  NACRES NA.32

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Core Bioreagents,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (HPLC)
  ≥98% (SDS-PAGE)
form   lyophilized
potency   1.0-3.0 μg/mL ED50
mol wt   5.6 kDa
packaging   pkg of 25 μg
application(s)   cell culture | mammalian: suitable
impurities   <0.1 EU/μg endotoxin, tested
color   white
UniProt accession no.   Q9NP84
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TNFRSF12A(51330)

Description

General description

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell’s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

Biochem/physiol Actions

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell’s apoptotic machinery. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

Sequence

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 50 mM NaCl.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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