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SRP3222 Sigma-Aldrich

MDC (CCL22) from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested

Synonym: ABCD-1, CCL22, Macrophage-Derived Chemokine, STCP-1

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Description

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Physical form

Lyophilized with no additives.

Biochem/physiol Actions

MDC chemoattracts monocytes, dendritic cells and natural killer (NK) cells and exerts human immunodeficiency virus (HIV) suppressive activity. It signals through the CCR4 receptor. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity.

General description

Macrophage-derived chemokine (MDC) is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and CD4 T cells. Recombinant murine MDC is a 7.8kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Sequence

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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