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SRP3262 Sigma-Aldrich

FGF-10 human

Animal-component free, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym: FGFA, Keratinocyte growth factor-2

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (HPLC)
  ≥95% (SDS-PAGE)
form   lyophilized
potency   ≥0.5 ng/mL
mol wt   mol wt 19.3 kDa
packaging   pkg of 25 μg
impurities   <0.1 EU/μg endotoxin, tested
color   white to off-white
UniProt accession no.   O15520
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... FGF10(2255)

Description

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in 5 mM Sodium Phosphate, pH 7.4 to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Physical form

Lyophilized from 5 mM Sodium Phosphate, pH 7.4 + 80 mM NaCl.

Biochem/physiol Actions

FGF10 (fibroblast growth factor 10) is involved in cell growth, morphogenesis and embryogenesis. It pays an essential role in initiating the formation of limb bud, lung morphogenesis and brain formation during embryogenesis. It acts as a mitogen where it facilitates the regeneration of epithelia post-bladder urothelial injury. Thus, it might have future applications during bladder transplantation. Studies in Japanese population show that polymosphisms- rs339501, rs12517396, and rs10462070 are linked with severe myopia, and might act as susceptibility factors for the same. In lung cancer cells, FGFR4 reduces the stem cell/self-renewal property of cancer cells, and makes them more susceptible to chemotherapy.

General description

FGF10 (fibroblast growth factor 10) is a member of the FGF protein family, and is a mitogen of epithelial origin and has paracrine activity. It is produced by mesenchymal lineage cells, and acts as a ligand for FGFR, most notably FGFR2b, which is expressed by epithelial cells.
Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast Growth Factors (FGFs) are potent regulators of cell proliferation, differentiation and function and are critically important in normal development, tissue maintenance, wound repair and ang...
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Peer-Reviewed Papers
15

References

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