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SRP3303 Sigma-Aldrich

FGF-ACIDIC rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym: ECGF-beta, FGF-1, HBGF-1

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Properties

Related Categories Angiogenesis, Angiogenic Factors, Cancer Research, Cell Biology, Cell Culture,
biological source   rat
recombinant   expressed in E. coli
assay   ≥95% (HPLC)
  ≥95% (SDS-PAGE)
form   lyophilized
potency   ≥1x10^7 units/mg
mol wt   15.9 kDa
packaging   pkg of 50 μg
impurities   <0.1 EU/μg endotoxin, tested
color   white to off-white
UniProt accession no.   P61149
shipped in   wet ice
storage temp.   −20°C
Gene Information   rat ... FGF1(25317)

Description

General description

Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors.

Biochem/physiol Actions

FGF-acidic is one of 23 known members of the FGF family. Recombinant rat FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.2 + 150 mM NaCl + 0.2% CHAPS.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in 5 mM Sodium Phosphate, pH 7.2 to a concentration of ≤0.5 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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