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SRP4066 Sigma-Aldrich

FGF-21 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: FGF21, FGFL, Fibroblast growth factor 21

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   mol wt ~19.5 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
NCBI accession no.   AB021975
UniProt accession no.   Q9NSA1
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... FGF21(26291)

Description

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

Physical form

Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.

Biochem/physiol Actions

FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.

General description

FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
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Peer-Reviewed Papers
15

References

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