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SRP4145 Sigma-Aldrich

IL-6 from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonym: B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, IFN-b2, MGI-2

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Properties

Related Categories CNTF Family - includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,
biological source   rat
recombinant   expressed in E. coli
assay   ≥90% (HPLC)
  ≥90% (SDS-PAGE)
form   lyophilized
potency   <0.01 ng/mL ED50
mol wt   ~21.7 kDa
packaging   pkg of 10 μg
impurities   endotoxin, tested
NCBI accession no.   P20607
shipped in   wet ice
storage temp.   −20°C
Gene Information   rat ... Il6(24498)

Description

General description

Interleukin- 6 (IL-6) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is a pro-inflammatory cytokine. IL-6 originates from mononuclear phagocytes, T and B lymphocytes, vascular endothelial cells and fibroblasts. It has a role in various physiological and pathological processes. IL-6 plays an important role in intracellular signaling pathways. Recombinant rat IL-6 is a 21.7kDa protein containing 187 amino acid residues.

Physical form

Lyophilized without any additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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